Publications

2021 - present

  1. Hedrick, S. L.; Luo, D.; Kaska, S.; Niloy, K.; Jackson, K.; Sarma, R.; Horn, J.; Baynard, C.; Leggas, M.; Butelman, E. R.; Kreek, M. J.; Prisinzano, T. E. Design, Synthesis, and Preliminary Evaluation of a Synthetic Opioid Rescue Agent. J. Biomed. Sci. 2021, 28, 62.
  2. Zamarripa, C. A.; Pareek, T.; Schrock, H. M.; Prisinzano, T. E.; Blough, B. E.; Sufka, K. J.; Freeman, K. B. The kappa-opioid agonist, Triazole 1.1, Reduces Oxycodone Self-Administration and Enhances Oxycodone-Induced Thermal Antinociception in Male Rats. Psychopharmacology (Berlin) 2021, in press.
  3. Wakeford, A. G. P.; Sherwood, A. M.; Prisinzano, T. E.; Bergman, J.; Kohut, S. J.; Paronis, C. A. Discriminative-stimulus effects of synthetic cathinones in squirrel monkeys. Int. J. Neuropsychopharmacol. 2021, 24, 656-665.
  4. Butelman, E. R.; Baynard, C.; McElroy, B. D.; Prisinzano, T. E.; Kreek, M. J. Profile of a short-acting k-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: Sex comparison in mice. J. Psychopharmacol. 2021, 35, 579-590.
  5. de Moura, F. B.; Sherwood, A. M.; Prisinzano, T. E.; Paronis, C. A.; Bergman, J.; Kohut, S. J. Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses. Pharmacol. Biochem. Behav. 2021, 202, 173112. PMC793861
  6. Denny, L.; Al Abadey, A.; Robichon, K.; Templeton, N.; Prisinzano, T. E.; Kivell, B. M.; La Flamme, A. C. Nalfurafine reduces neuroinflammation and drives remyelination in models of CNS demyelinating disease. Clin. Transl. Immunology 2021, e1234, doi: 10.1002/cti2.1234

2020 - 2021

  1. Doss, M. K.; May, D. G.; Johnson, M. W.; Clifton, J. M.; Hedrick, S. L.; Prisinzano, T. E.; Griffiths, R. R.; Barrett, F. S. The Acute Effects of the Atypical Dissociative Hallucinogen Salvinorin A on Resting State Functional Connectivity in the Human Brain. Sci. Rep. 2020, 10, 16392. PMC7532139
  2. Paton, K.; Atigari, D. V.; Kaska, S.; Prisinzano, T. E.; Kivell, B. M. Strategies for developing kappa opioid receptor agonists for the treatment of pain with fewer side-effects. J. Pharmacol. Exp. Ther. 2020, 375, 332-348. PMC758995
  3. Zamarripa, C. A.; Naylor, J. E.; Huskinson, S. L.; Townsend, E. A.; Prisinzano, T. E.; Freeman, K. B. The kappa-opioid receptor agonist, nalfurafine, blocks acquisition of oxycodone self-administration and oxycodone’s conditioned rewarding effects in male rats. Behav. Pharmacol. 2020, 31, 792-797.
  4. Gutman, E.; Bow, E.; Li, F.; Sulima, A.; Kaska, S.; Crowley, R. S.; Prisinzano, T. E.; Lee, Y. S.; Imler, G. H.; Hassan, S. A.; Deschamps, J. R.; Jacobson, A. E.; Rice, K. C. G-Protein biased opioid agonists: 3-hydroxy-N-phenethyl-5-phenylmorphans with three-carbon chain substituents at C9. RSC Med. Chem. 2020, 11, 896-904. PMC7557571
  5. Paton, K.; Ewald A.; Biggerstaff, A.; Kaska, S.; Crowley, R. S.; La Flamme, A.; Prisinzano, T. E.; Kivell, B. M. Evaluation biased and balanced salvinorin A analogues in preclinical models of pain. Front Neurosci. 2020, 14, 765. PMC7385413
  6. Huskinson, S. L.; Platt, D. M.; Brasfield, M.; Follett, M. E.; Prisinzano, T. E.; Blough, B. E.; Freeman, K. B. Quantification of observable behaviors induced by kappa opioid agonists in male rhesus monkeys. Psychopharmacology (Berlin) 2020, 237, 2075-2087. PMC730820
  7. Crowley, R. S.; Riley, A. P.; Alder, A. F.; Anderson III, R. J.; Luo. D.; Kaska, S.; Maynez, P.; Kivell, B. M.; Prisinzano, T. E. Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-Protein Activation Bias at m Opioid Receptors. ACS Chem. Neurosci. 2020, 11, 1781-1790. PMC7359744
  8. Wang, M.; Irvin, T. C.; Herdan, C. A.; Hassan, S. A.; Lee, Y-S.; Kaska, S.; Crowley, R. S.; Prisinzano, T. E.; Withey, S. L.; Paronis, C. A.; Bergman, J.; Geller, E.; Adler, M. W.; Kopajtic, T. A.; Katz, J. L.; Chadderdon, A. M.; Traynor, J. R.; Jacobson, A. E.; Rice, K. C. The Intriguing Effects of Substituents in the N-Phenethyl Moeity of Norhydromorphone. A Set of “Tail Wags Dog” Experiments. Molecules 2020, 25, 2640; doi:10.3390/molecules25112640. PMC7321161
  9. Zamarripa, C. A.; Naylor, J. E.; Huskinson, S. L.; Townsend, E. A.; Prisinzano, T. E.; Freeman, K. B. Kappa Opioids Reduce Oxycodone Self-Administration in Male Rhesus Monkeys. Psychopharmacology (Berlin) 2020, 237, 1471-1480. PMC719651
  10. Hunt, J. R.; Kleindl, P. A.; Moulder, K. R.; Prisinzano, T. E.; Forrest, M. L. Further Exploration of the Structure-Activity Relationships of Imidazoquinolines; Identification of Potent C7 Substituted Imidazoquinolines. Bioorg. Med. Chem. Lett. 2020, 30, 126788. PMC694220